17#nowave, {' g9 J6 u0 M, x
You are right. Thanks for the correction. - Y& \$ \3 U N y4 n. F/ dI did not check the mechanism of Tamiflu. * S- Y4 i* e7 |; A
Actually, this mechanism is very interesting. Do you think it will work on bacterials?
20#vilna ! |. S* K G1 Y& |They are quite different. 9 c5 F- B2 Q# N9 UAs far as I know, no good drug is effecient to viruses. 2 ^* s" Z/ r* \$ g+ y
For bacterials, new drug and new mechanism are needed.
20# vilna ; O& w, o& ^9 r) V6 h2 |They are quite different. ) ~6 f& @, Y/ N9 NAs far as I know, no good drug is effecient to viruses. 2 \2 [4 m, s1 K4 R
For bacterials, new drug and new mechanism are needed.9 K6 {& ^* B7 ^8 H
衣食住行 发表于 2009-6-30 11:54
23#vilna 7 @& E7 C# Y t r/ nGreat. Could you please give a description of them briefly? ; r+ m w' M; @) ?. ~Looks like that you guys have excellent background on medicines. I am a chemist working in a pharmaceutical company. I am quite interested in those medicinal news so that we can design good organic compound. ! w- m5 C# b% W
For anti-bacterial, we can attack their cell membrane, block their DNA-RNA replication, ect. But the problem is their PBP. If we don't need to peneatrate into their membrane, that would be very interesting. 6 y1 _' ]( T9 L2 D
For viruses, we have not done much work. But I know the market needs drugs, the more, the better. m1 l2 |1 T# w; zB.T.W., from your point of view, how to avoid or solve drug-resistance problem?
23# vilna 8 A# o5 Y6 H ?) _/ C4 n, |1 m) TGreat. Could you please give a description of them briefly? 9 A% X O( h% z7 @, O0 X0 A
Looks like that you guys have excellent background on medicines. I am a chemist working in a pharmaceutical company. I am qui ... 8 K) F: N! p' U, c; k" r& M衣食住行 发表于 2009-6-30 14:21
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你这可是大题目呀,打算让我们写综述? ! W) m' {5 C( e; Y5 N' `, y2 p, n' N. W
总的说来,病毒类药物主要是根据病毒的复制而针对性开发的,主要有以下几类:& B/ s: ^4 r G( i s
1,抑制病毒吸附、侵入或逸出的药物。如金刚烷胺类。奥司他韦也属于这类。4 y- [! [0 B. J
2,抑制病毒核酸复制和合成的药物。如利巴韦林 : m6 |) X9 P) ?3,抑制病毒蛋白质合成的药物。如甲红硫脲! |' i* V1 _$ ]6 a M& l5 G& i5 b
4,调节免疫系统的药物。如干扰素 0 @5 f h, E& Q e$ d--------/ R$ ~# A1 }6 ^
抗药性问题:, J" z, h3 \% F! E8 ]; z: K
从个体来说,主要是不滥服抗病毒药物和抗生素,以免产生抗性。从整体说:这就和电脑的杀毒软件和电脑病毒一样,是在不断拮抗之中的。当然如果不对动物和人滥用抗生素,抗药性情况会更好些。